Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress

  • July 28, 2014 | Melanie Ricke-Hoch1†, Insa Bultmann1,2† Ursula Rinas4, Karen Sliwa5, Michaela Scherr6, and Denise Hilfiker-Kleiner1* , Britta | Category: HEDUAfrica news

Photo courtesy of Nicolas Raymond

Postpartum Akt activation is detrimental for the peripartum heart as it lowers anti-oxidative defence and in combination with low STAT3 conditions, accelerate cardiac inflammation and fibrosis. PRL and its cleaved 16 kDa form are central for Akt-induced PPCM as indicated by the protection from the disease by PRL blockade.

Peripartum cardiomyopathy (PPCM) is a pregnancy-associated cardiomyopathy in previously healthy women. Mice with a cardiomyocyte-restricted deletion of signal transducer and activator of transcription-3 (STAT3, CKO) develop PPCM. PI3K-Akt signalling is thought to promote cardiac hypertrophy and protection during pregnancy.We evaluated the role of activated Akt signalling in the maternal heart postpartum.

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